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Component architecture registry local to this application.

Invoke the Pyramid request pipeline.

See Request Processing for information on the request pipeline.

The output should be a pyramid.interfaces.IResponse object or a raised exception.

Return an object which implements pyramid.interfaces.IViewMapper . kw will be a dictionary containing view-specific arguments, such as permission , predicates , attr , renderer , and other items. An IViewMapperFactory is used by pyramid.config.Configurator.add_view() to provide a plugpoint to extension developers who want to modify potential view callable invocation signatures and response values.

Provided with an arbitrary object (a function, class, or instance), returns a callable with the call signature (context, request) . The callable returned should itself return a Response object. An IViewMapper is returned by pyramid.interfaces.IViewMapperFactory .

Set a key/value pair into the dictionary

Return True if key k exists in the dictionary.

Return a list of keys from the dictionary

Pop the item with key k from the dictionary and return it as a two-tuple (k, v). If k doesn't exist, raise a KeyError.

Return the value for key k from the renderer dictionary, or the default if no such value exists.

Return a list of values from the dictionary

Pop the key k from the dictionary and return its value. If k doesn't exist, and default is provided, return the default. If k doesn't exist and default is not provided, raise a KeyError.

Return an iterator over the keys of this dictionary

Delete an item from the dictionary which is passed to the renderer as the renderer globals dictionary.

Update the renderer dictionary with another dictionary d .

Return the existing value for key k in the dictionary. If no value with k exists in the dictionary, set the default value into the dictionary under the k name passed. If a value already existed in the dictionary, return it. If a value did not exist in the dictionary, return the default

Clear all values from the dictionary

Return a list of [(k,v)] pairs from the dictionary

Return the value for key k from the dictionary or raise a KeyError if the key doesn't exist

Figure 2.
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Validation brain data from human immunodeficiency virus (HIV)–infected subjects (cases) and HIV-uninfected subjects (controls). Analogous to Figure 1 , we used independent data sets (data 2 and 3) to relate HIV status to epigenetic age acceleration in the frontal lobe and cerebellum of cases and controls. and , DNA methylation (DNAm) age versus chronological age in cerebellum () and frontal lobe () samples. Points (subjects) are colored by HIV status: cases correspond to red squares. The orange and black lines depict regression lines case and control samples, respectively. The measure of age acceleration is the same as used in Figure 1 . and , Age acceleration versus HIV status in cerebellum () and frontal lobe () specimens. Each bar plot reports the Kruskal–Wallis (nonparametric) group comparison test value and 1 standard error around the mean. Abbreviation: cor, correlation.

Figure 2.
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Validation brain data from human immunodeficiency virus (HIV)–infected subjects (cases) and HIV-uninfected subjects (controls). Analogous to Figure 1 , we used independent data sets (data 2 and 3) to relate HIV status to epigenetic age acceleration in the frontal lobe and cerebellum of cases and controls. and , DNA methylation (DNAm) age versus chronological age in cerebellum () and frontal lobe () samples. Points (subjects) are colored by HIV status: cases correspond to red squares. The orange and black lines depict regression lines case and control samples, respectively. The measure of age acceleration is the same as used in Figure 1 . and , Age acceleration versus HIV status in cerebellum () and frontal lobe () specimens. Each bar plot reports the Kruskal–Wallis (nonparametric) group comparison test value and 1 standard error around the mean. Abbreviation: cor, correlation.

Overall, HIV load in the CSF of cases was not significantly correlated with age acceleration in the brain samples (Figure 1 I K ), but there was a marginally significant effect in the frontal lobe ( r = 0.42, P = .065; Figure 1 L ). Since viral load was not ascertained in brain tissue, we could not correlate it with epigenetic age acceleration in the respective brain regions.

More-detailed examination is required to determine the cellular and histopathological correlates of age acceleration in HIV-infected brains. Table 2 provides clinical information about the cases from whom autopsy brain samples were analyzed. Unfortunately, cause of death is not collected by the NNTC, although these data are often unreliable because of the multiple comorbidities of the participants. However, and more relevant, considering that we examined brain DNA, the NNTC conducts neuropathological examination according to a standard protocol. While the brain pathologies from HIV-infected individuals do not necessarily translate to specific diseases or clinical syndromes and are not uncommon in individuals with advanced HIV infection, these data indicated that, of the 31 cases with noted brain pathology, several had >1 type. All cases received a diagnosis ≤1 year prior to death indicating that they were neurocognitively normal or had an HIV-associated neurocognitive disorder (as reported elsewhere [ 33 ]). We also included in Table 2 virologic and clinical variables. Note that in some instances this information was not collected. According to the autopsy results, 8 cases had HIV-associated encephalitis. Greater number of perivascular macrophages are found in the brains of patients with HIV encephalitis [ 43 ]. While we cannot rule out that the observed age acceleration effects reflect changes in cellular composition (eg, increased numbers of perivascular macrophages), we could not find a significant relationship between epigenetic age acceleration effects in brain samples from cases and a marker of activated macrophages, namely ionized calcium-binding adapter molecule 1 (IBA1), which is encoded by the gene allograft inflammatory factor 1. The IBA1 marker was assessed using immunohistochemical staining of paraffin embedded tissue, as described in “Methods” section.

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Configure OAuth 2.0 for SAP ByDesign OData Services

July 13, 2018 | 41 Views |
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OData services support two authentication protocols: (user/password) and .

This blog posts provides an example to configure principal propagation using between an running on the (SCP) and (ByD) using OData services.

Example scenario:

Let’s assume we have an running on the (SCP) to display and browse your company address book and allow employees to change their workplace address information. The HTML5 application is connected to as cloud ERP backend with all relevant employee data stored.

Users shall be able to use the same logon credentials for the SCP HTML5 application as well as for usingfrontend single sign-on,and user propagation shall be used for any OData requests between the SCP application and ByD.

In my example I’m using the following system setup:

In my blog post Extend SAP ByDesign using SAP Cloud Platform HTML5 Applications I explained how to setup an running on the to extend .

Now we will adapt this setup in 3 steps to apply frontend Single Sign-On and principal propagation using OAuth 2.0 SAML Bearer authentication :

Step 1: Setup Single Sign-On for the SCP HTML5 Application

As first step we setup frontend single sign-on to use as Identity provider for the HTML5 demo application.

SCP: Capture all relevant information to configure the IDP and later on OAuth:

IDP : Add the SCP as application to the identity provider list of applications:

IDP : Capture the IDP metadata from the tenant:

SCP : Add thetenantas trusted identity provider:

Result:

You can test single sign-on for your SCP HTML5 Application: Capture the of your SCP HTML5 application and open the URL in an incognito browser window. The browser should redirect you to the IDP logon screen for authentication and you should be able to successfully login to the SCP HTML5 application.

Step 2: Setup Single Sign-On for SAP Business ByDesign

In step 2 we setup frontend single sign-on to use as Identity provider for SAP Business ByDesign.

ByD : Configure Single Sign-on:

IDP : Add the ByD tenant as application on the identity provider:

Result:

You can login to theByD tenant using single sign-on: Open the SSO-URL of your ByD tenant in an incognito browser window (for example “). The browser should redirect you to the IDP logon screen for authentication and you should be able to successfully login to ByD.

Some remarks:

Per default ByD uses the name ID format “unspecified” for user mapping. ByD maps the name ID of SAML-assertions on the ByD user alias.

Additionally ByD support the name ID format “emailAddress“. In this case ByD maps the name ID of the SAM-assertion on the ByD user e-mail address that is specified in the ByD employee contact data.

Step 3: Configure OAuth 2.0 SAML Bearer Authentication

In step 1 and 2 we configured frontend single sign-on for SAP ByDesign and the SAP Cloud Platform application.Now we configure principal propagation such that the same user is used for OData access between the SCP application and ByD as well.

ByD : Configure an OAuth 2.0 Identity Provider

ByD : Add an OAuth2.0 Client Registration

SCP : Create a Destination with OAuth 2.0 SAML Bearer authentication

Enter the Additional Properties:

Result:

The SCP HTML5 Application now uses user propagation for accessing ByD using the OData services. Open the of your HTML5 application in an incognito browser window: The browser should redirect you to the IDP logon screen for authentication (frontend single sign-on configured in step 1) and the role-based authorizations of your mapped ByD user should apply in the HTML5 application for read and write access to ByD (user propagation configured in step 3).

Remarks and additional information

In my example above I used a single SCP sub-account to develop and use the HTML5 appication.

In a productively used scenario I would rather suggest to separate provisioning and consumption of the SCP application, which adds one more SCP sub-account to the system setup:

In this setup the subscribes to the HTML5 application provided by the using the >> screen. In the configuration of the subscription you get the and you have the possibility to map required destinations as described in step 3.

Furthemore frontend single sign-on and OAuth 2.0 SAML Bearer Authentication is to be configured in the as well.

Related information using OAuth 2.0 in SAP Business ByDesign and SAP Cloud for Customer:

SAP Business ByDesign

Like a snake eating its own tail, it was the later move towards rationalism – built on a belief in man’s transcendence – that eventually toppled our hubristic sensibilities. With the advent of Charles Darwin’s theories, later confirmed through geology, palaeontology and genetics, humans struggled mightily and vainly to erect a scientific blockade between beasts and ourselves. We believed we occupied a glorious perch as a thinking thing. But over time that rarefied category became more and more crowded. Whichever intellectual shibboleth we decide is the ability that sets us apart, it’s inevitably found to be shared with the chimp. One can resent this for the same reason we might baulk at Ivanov’s experiments: they bring the nature of the beast a bit too close.

The chimp is the opener in a relay race that repeats itself time and again in the study of animal behaviour. Scientists concoct a new, intelligent task for the chimps, and they do it – before passing down the baton to other primates, who usually also manage it. Then they hand it on to parrots and crows, rats and Womens Pckarmen Striped Shirt Noos Blouse Pieces Cheap Visit New 4BeykjqBzN
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Some of these proposed watersheds, such as tool-use, are old suggestions, stretching back to how the Victorians grappled with the consequences of Darwinism. Others, such as imitation or empathy , are still denied to non-humans by certain modern psychologists. In Are We Smart Enough to Know How Smart Animals Are? (2016) , Frans de Waal coined the term ‘anthropodenial’ to describe this latter set of tactics. Faced with a potential example of culture or empathy in animals, the injunction against anthropomorphism gets trotted out to assert that such labels are inappropriate. Evidence threatening to refute human exceptionalism is waved off as an insufficiently ‘pure’ example of the phenomenon in question (a logical fallacy stud detail slippers Black Toga Archives Very Cheap Online Lowest Price Online Shop From China Outlet Visa Payment WaibKp
as ‘no true Scotsman’). Yet nearly all these traits have run the relay from the ape down – a process deWaal calls ‘cognitive ripples’, as researchers find a particular species characteristic that breaks down the barriers to finding it somewhere else.

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T ool-use is the most famous, and most thoroughly defeated, example. It transpires that chimps use all manner of tools, from sticks to extract termites from their mounds to stones as a hammer and anvil to smash open nuts. The many delightful antics of New Caledonian crows have received particular attention in recent years. Among other things, they can use multiple tools in sequence when the reward is far away but the nearest tool is too short and the larger tools are out of reach. They use the short tool to reach the medium one, then that one to reach the long one, and finally the long tool to reach the reward – all without trial and error.

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